Anyone else see this; where your home screen shortcuts or icons just disappear during use??

I have the Moto Droid; 2.1. It happened a few times now in the past few months (not often), but happened twice today. I'm using the Messaging app or a game app, go back to Home and it's blank except for my background image. You can flip up and gain access to all the apps and everything works but the home screen is blank.

Only way to fix is to turn off, power down, and restart.

Any ideas?